What is the science behind Alzheimer's disease

New study: is Alzheimer's disease curable?

Is it possible that one of the greatest and most worrying mysteries of human aging was revealed a few weeks ago? Researchers at Rutgers University (USA) do not rule out this possibility.

It is well known that scientists are still unable to pinpoint the exact cause of Alzheimer's disease. A popular theory is that amyloid beta proteins lead to protein deposits called amyloid plaques between neurons in the brain. In the healthy brain, these fragments are broken down and destroyed. In Alzheimer's disease, however, they accumulate to form hard, indissoluble plaques.

Now the uncertainty seems to have come to an end. Rutgers University researchers, led by Professor Federico Sesti, are investigating a way to treat Alzheimer's disease. The key could be a protein called KCNB1. It is produced by oxidation in a brain affected by Alzheimer's under the influence of stress - and promotes the production of beta-amyloid protein.

“The discovery of this oxidation process and the structure of KCNB1 was made through observation of changes in the brains of mice and humans. This finding is of great importance, since most studies often do not go beyond the observation of animals, ”explains Professor Sesti.

Following this discovery, the research team has already successfully tested an inhibitory drug called Sprycel in mice. It has been shown that this or similar inhibiting drugs can very likely reduce the formation of plaques. A clinical study to test this drug in humans is pending in the near future and gives hope for promising and revolutionary results.

Treating Alzheimer's - or would you rather prevent it?

If you do not rely on future medication, but want to actively prevent Alzheimer's dementia now, we recommend that you consult your brain training program regularly: Personalized and scientifically tested exercises from NeuroNation, together with a correct lifestyle, form a reliable basis for a long and fulfilling lifestyle Life.

Swell:

Yu Wei, Mi Ryung Shin, Federico Sesti. Oxidation of KCNB1 channels in the human brain and in mouse model of Alzheimer's disease. Cell Death & Disease, 2018; 9 (8)