Is acetic anhydride soluble in water

Acetic anhydride C.4H6O3 

Clear, colorless liquid
molar mass 102.089 g / mol

AGW0.1 ml / m3 (TRGS 900)
density 1.082 g / cm3   
Melting point −73.4 ° C
boiling point +139.5 ° C
Water solubility decomposes
Refractive index (20 ° C)  1,3901
Explosion limit 2.7 to 10.3% by volume (air)
Flash point +49 ° C
Ignition point +316 ° C

GHS 02
GHS 05
GHS 06
Hazard classes + category 
Flammable liquids 3
Acute toxicity oral 4
Acute toxicity inhalation 3
Skin corrosion / irritation 1B
Specific target organ toxicity 3 (respiratory tract)
HP rates (see also note)     
H 226, 302, 314, 331, 335
P 210, 260, 280.1-4 + 7, 312, 303 + 361 + 353, 305 + 351 + 338

Pretreatment required
Print a labelGerman designation 
Synonyms (German)
English designation 
CAS 108-24-7Acetic anhydride
Acetic anhydride
Acetic anhydrides
Note for schools: acetic anhydride reacts with water, with acids and alkalis and with alcohols. Disposal regulations must be observed. The pungent smelling and tear-irritating liquid is toxic when inhaled and corrodes skin and eyes. When working, protective goggles, protective gowns, protective gloves made of butyl rubber and a face shield must be worn. Working in the fume cupboard is recommended.
Acetic anhydride is a colorless, clear liquid that has a strong smell and is irritating to the eyes. When water is added, it decomposes to acetic acid; when alcohol is added, an ester is formed. The decomposition in water takes place much faster in hot water or when acids are added. The boiling point is higher than that of acetic acid.

Acetic anhydride is formed when two molecules of acetic acid react with elimination of water. The two carboxy groups of acetic acid combine in this process. To achieve this, acetic acid is first converted into a ketene with elimination of water, which then adds to the acetic acid. Another industrial production possibility would be the oxidation of acetaldehyde on the copper acetate contact. In the laboratory, acetic anhydride can be obtained by reacting acetyl chloride with sodium acetate:


Acetic anhydride is a major acetylating agent. It is required for the production of cellulose acetate, which is used in numerous applications as a textile fabric, for example in textiles or in the optical layers of smartphone monitors. Salicylic acid reacts with acetic anhydride in the manufacture of the pain reliever drug acetylsalicylic acid, known under the brand name aspirin. The acetic anhydride trade is monitored as it is an important raw material in the synthesis of diacetylmorphine (heroin) from morphine.